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Sheldon Sloan

SYRE
CHIEF MEDICAL OFFICER · SPYRE THERAPEUTICS, INC. · CIK 0002038798
FILING MIX · LIFETIME32%/68%
BUYS
7
SELLS
15
TOTAL VALUE
$10.14M
COMPANIES
1
ACTIVE SINCE
Oct 2024
HOLDINGS NOW
1,834
AVG SELL PX
$71.43
TRADE KIND
SHOWING 22 / 22
Trades · vs SPY
Loading price series…
Performance · forward returns vs SPY
8 backtested trades · 8 horizons · 31 pending
Forward-return performance of every backtestable P/S trade by Sheldon Sloan, measured at 8 horizons from 7 days to 2 years. Deduped per economic event so co-filings count once. Excess return = trade return minus SPY return over the same window.
HORIZONTRADESWIN RATEINSIDER RETURNSPY RETURNMEAN EXCESSMEDIAN EXCESST-STAT
7d8+0.00%+7.88%+2.46%+5.42%+5.75%
14d8+0.00%+13.82%+3.48%+10.34%+6.92%
30d8+0.00%+10.39%+9.98%+31.98%+31.98%
60d8+0.00%+30.55%+2.82%+24.91%+24.91%
90d8(7 pending)+0.00%+81.33%+13.09%+68.24%+68.24%
180d8(8 pending)
1y8(8 pending)
2y8(8 pending)
How to read this: Insider Returnis the average raw return of the filer's trades over the horizon. SPY Return is what SPY did over those same windows — reference only, not a comparison. The headline alpha number is Mean Excess = Insider − SPY; green means the filer beat SPY, red means they trailed it. Win rate is the share of individual trades where the filer beat SPY. T-statvalues above 2 mean the alpha is unlikely to be chance given the sample size. "Pending" counts trades where the horizon hasn't elapsed yet; their stats are not included in the row average.
Holdings over time
SYRE · 1,834 shares · as of Jul 1, 2026
0100,000200,000300,000400,00020252026SHARES HELD
Trading cadence · quarterly flow
BUY SELL
2024
2025
2025
2025
2025
2026
2026
2026
FLOW · 7 buys / 15 sellsCOVERAGE · 8 quarters
Form 4 filings · all activity
COMPANYTYPESHARESPRICEVALUEHELD AFTERTRADE DATEFILEDDETAILS
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
6,500$87.52$568.9K1,834Jul 1, 2026Jul 2, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASE
Chief Medical Officer
8,334$27.46$228.9K8,334Jul 1, 2026Jul 2, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
1,834$88.34$162.0K0Jul 1, 2026Jul 2, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE
Chief Medical Officer
8,334305,000Jul 1, 2026Jul 2, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE
Chief Medical Officer
8,333313,334Jun 3, 2026Jun 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
8,333$75.00$625.0K0Jun 3, 2026Jun 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASE
Chief Medical Officer
8,333$27.46$228.8K8,333Jun 3, 2026Jun 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
400$75.37$30.1K0May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASE
Chief Medical Officer
78,333$27.46$2.15M78,333May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
5,059$74.60$377.4K400May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
19,656$70.61$1.39M37,371May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE
Chief Medical Officer
78,333321,667May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
21,306$69.53$1.48M57,027May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
12,777$72.94$932.0K15,817May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
8,777$71.56$628.1K28,594May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
10,358$73.74$763.8K5,459May 1, 2026May 1, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASE
Chief Medical Officer
7,958$21.66$172.4K7,958Apr 1, 2026Apr 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE
Chief Medical Officer
7,95887,542Apr 1, 2026Apr 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
SALE10b5-1
10b5-1 plan
7,958$50.00$397.9K0Apr 1, 2026Apr 3, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASEGRANT
Stock grant
140,000140,000Jan 9, 2026Jan 13, 2026View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASEGRANT
Stock grant
95,50095,500Jan 15, 2025Jan 17, 2025View →
SYRE
SPYRE THERAPEUTICS, INC.
PURCHASEGRANT
Stock grant
400,000400,000Oct 1, 2024Oct 1, 2024View →
Other insiders · SYRE
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About this filer
CIK 0002038798
ROLE
Chief Medical Officer
PRIMARY
SYRE
COMPANIES
1
ACTIVE SINCE
Oct 2024
MARKETPEEL · /INSIDER/0002038798DATA · SEC EDGAR · FORM 4 · CONSOLIDATED TAPE
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