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Carole Ho

DNLI
CHIEF MEDICAL OFFICER · DENALI THERAPEUTICS INC. · CIK 0001724605
FILING MIX · LIFETIME33%/67%
BUYS
35
SELLS
72
TOTAL VALUE
$7.80M
COMPANIES
3
ACTIVE SINCE
Nov 2018
HOLDINGS NOW
254,792
AVG SELL PX
$30.48
TRADE KIND
SHOWING 107 / 107
Trades · vs SPY
Loading price series…
Performance · forward returns vs SPY
47 backtested trades · 8 horizons · 8 pending
Forward-return performance of every backtestable P/S trade by Carole Ho, measured at 8 horizons from 7 days to 2 years. Deduped per economic event so co-filings count once. Excess return = trade return minus SPY return over the same window.
HORIZONTRADESWIN RATEINSIDER RETURNSPY RETURNMEAN EXCESSMEDIAN EXCESST-STAT
7d47+65.96%-3.35%-0.23%-3.12%-2.93%-2.91
14d47+59.57%-1.54%-0.15%-1.40%-5.16%-1.00
30d47+57.45%+0.88%+0.70%+0.18%-1.92%0.08
60d47+70.21%-0.16%+2.82%-2.98%-12.39%-0.74
90d47+65.96%+1.25%+4.45%-3.20%-9.83%-0.71
180d47+70.21%-4.67%+10.27%-14.94%-25.02%-3.78
1y47(2 pending)+77.78%-21.09%+15.91%-37.00%-53.48%-7.24
2y47(6 pending)+92.68%-37.47%+24.73%-62.19%-62.13%-21.87
How to read this: Insider Returnis the average raw return of the filer's trades over the horizon. SPY Return is what SPY did over those same windows — reference only, not a comparison. The headline alpha number is Mean Excess = Insider − SPY; green means the filer beat SPY, red means they trailed it. Win rate is the share of individual trades where the filer beat SPY. T-statvalues above 2 mean the alpha is unlikely to be chance given the sample size. "Pending" counts trades where the horizon hasn't elapsed yet; their stats are not included in the row average.
Holdings over time
DNLI · 216,585 shares · as of Aug 13, 2025
055,082110,164165,246220,3282019202020212022202320242025SHARES HELD
Trading cadence · quarterly flow
BUY ● SELL ●
2018
2019
2019
2019
2019
2020
2020
2020
2020
2021
2021
2021
2021
2022
2022
2022
2022
2023
2023
2023
2023
2024
2024
2024
2024
2025
2025
2025
2025
2026
2026
FLOW · 35 buys / 72 sellsCOVERAGE · 31 quarters
Form 4 filings · all activity
COMPANYTYPESHARESPRICEVALUEHELD AFTERTRADE DATEFILEDDETAILS
RPRX
ROYALTY PHARMA PLC
PURCHASEGRANT
Stock grant
4,545——4,545Jun 5, 2026Jun 8, 2026 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
806$14.64$11.8K216,585Aug 13, 2025Aug 14, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
2,937$13.58$39.9K217,391Aug 12, 2025Aug 14, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
44,655$0.68$30.4K220,328Aug 5, 2025Aug 7, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
44,655——62,500Aug 5, 2025Aug 7, 2025 ↗View →
RPRX
ROYALTY PHARMA PLC
PURCHASEGRANT
Stock grant
5,806——8,558Jul 31, 2025Jul 31, 2025 ↗View →
RPRX
ROYALTY PHARMA PLC
PURCHASEGRANT
Stock grant
2,752——2,752Jul 31, 2025Jul 31, 2025 ↗View →
BEAM
BEAM THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
33,662——33,662Jun 4, 2025Jun 6, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,907$20.81$60.5K175,673Jan 7, 2025Jan 8, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
12,255$20.22$247.8K178,580Jan 6, 2025Jan 8, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
162,540——162,540Jan 3, 2025Jan 7, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
54,180——190,835Jan 3, 2025Jan 7, 2025 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
17,845$0.68$12.1K136,655Nov 25, 2024Nov 27, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
17,845——107,155Nov 25, 2024Nov 27, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
14,098$24.41$344.1K124,717Aug 21, 2024Aug 22, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
5,907$24.96$147.4K118,810Aug 21, 2024Aug 22, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
2,453$23.79$58.4K138,815Aug 20, 2024Aug 22, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,337$22.89$53.5K141,268Aug 13, 2024Aug 15, 2024 ↗View →
BEAM
BEAM THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
23,114——23,114Jun 5, 2024Jun 7, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
1,405$17.79$25.0K143,605Feb 14, 2024Feb 15, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
2,784$17.29$48.1K145,010Feb 13, 2024Feb 15, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
4,668$19.02$88.8K147,794Jan 10, 2024Jan 12, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
9,972$19.43$193.8K198,777Jan 5, 2024Jan 9, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
161,160——161,160Jan 3, 2024Jan 5, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
53,720——162,434Jan 3, 2024Jan 5, 2024 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,522$23.22$58.6K182,809Aug 23, 2023Aug 25, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,478$22.60$56.0K185,331Aug 21, 2023Aug 23, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE10b5-1
10b5-1 plan
2,768$23.79$65.9K182,809Aug 14, 2023Aug 16, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,857$24.15$69.0K185,577Aug 10, 2023Aug 14, 2023 ↗View →
BEAM
BEAM THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
16,532——16,532Jun 6, 2023Jun 8, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,476$29.40$43.4K182,809Feb 15, 2023Feb 17, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,548$30.10$76.7K184,285Feb 13, 2023Feb 14, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
818$29.80$24.4K179,365Feb 10, 2023Feb 14, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,521$30.88$47.0K180,183Feb 8, 2023Feb 10, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,459$28.48$41.6K177,454Jan 9, 2023Jan 10, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,451$28.67$41.6K178,913Jan 6, 2023Jan 9, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,636$28.44$75.0K180,364Jan 5, 2023Jan 9, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,913$28.69$83.6K175,500Jan 4, 2023Jan 5, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
41,120——138,967Jan 3, 2023Jan 5, 2023 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
123,360——123,360Jan 3, 2023Jan 5, 2023 ↗View →
BEAM
BEAM THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
10,391——10,391Sep 1, 2022Sep 2, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,424$31.98$77.5K170,663Aug 23, 2022Aug 25, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,576$33.22$85.6K173,087Aug 19, 2022Aug 23, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
22,500——110,597Aug 9, 2022Aug 11, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,918$34.71$101.3K170,663Feb 11, 2022Feb 15, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,423$37.10$52.8K166,112Feb 9, 2022Feb 11, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,845$44.78$127.4K163,285Jan 5, 2022Jan 7, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
93,000——93,000Jan 3, 2022Jan 5, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
31,000——107,316Jan 3, 2022Jan 5, 2022 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,476$42.52$62.8K76,316Dec 6, 2021Dec 8, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
6,143$48.91$300.5K158,630Aug 23, 2021Aug 25, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,402$49.31$69.1K165,917Aug 19, 2021Aug 23, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,144$49.91$57.1K164,773Aug 19, 2021Aug 23, 2021 ↗View →
BEAM
BEAM THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
6,877——6,877Jun 10, 2021Jun 14, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,822$54.62$154.1K162,319Mar 29, 2021Mar 31, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,327$64.54$85.6K170,906Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
68$71.27$4.8K165,141Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
125$70.07$8.8K165,209Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,320$68.01$89.8K165,542Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,173$67.07$78.7K166,862Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
208$68.87$14.3K165,334Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,871$65.74$188.7K168,035Mar 1, 2021Mar 3, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
2,756$70.17$193.4K172,633Feb 11, 2021Feb 16, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
400$71.49$28.6K172,233Feb 11, 2021Feb 16, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
100$76.00$7.6K167,921Feb 9, 2021Feb 11, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
364$75.10$27.3K168,021Feb 9, 2021Feb 11, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,006$74.40$74.8K168,385Feb 9, 2021Feb 11, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
4,250——8,500Feb 7, 2021Feb 11, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
4,250——169,391Feb 7, 2021Feb 11, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
90,000——90,000Jan 4, 2021Jan 6, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
30,000——30,000Jan 4, 2021Jan 6, 2021 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
10,465$40.68$425.7K186,152Oct 9, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
30,000——38,240Oct 9, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
19,535$41.51$810.9K166,617Oct 9, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
30,000$5.28$158.4K196,617Oct 9, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
9,886——68,240Oct 8, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
22,906$5.28$120.9K189,523Oct 8, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
13,020——44,035Oct 8, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
22,906$40.12$919.0K166,617Oct 8, 2020Oct 13, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
3,689$31.00$114.4K165,141Sep 10, 2020Sep 14, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,954$32.88$64.2K6,511Aug 21, 2020Aug 24, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
5,643——8,465Aug 20, 2020Aug 24, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
5,643——0Aug 20, 2020Aug 24, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
20,000——20,000Aug 18, 2020Aug 20, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,428$19.48$27.8K2,822Mar 30, 2020Apr 1, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
142,000——142,000Feb 10, 2020Feb 12, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASEGRANT
Stock grant
29,874——29,874Feb 10, 2020Feb 12, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
4,250——12,750Feb 7, 2020Apr 1, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
4,250——4,250Feb 7, 2020Apr 1, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
1,500$19.30$28.9K182,575Jan 4, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
5,950——66,875Jan 4, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
5,950$5.28$31.4K184,075Jan 4, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
4,450$20.03$89.1K178,125Jan 4, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
5,775$5.28$30.5K183,900Jan 3, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
5,775$18.90$109.1K178,125Jan 3, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
5,775——72,825Jan 3, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
900$20.24$18.2K178,125Jan 2, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
5,775$5.28$30.5K183,900Jan 2, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
5,775——78,600Jan 2, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
4,875$19.43$94.7K179,025Jan 2, 2019Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
400$19.16$7.7K178,125Dec 3, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
17,100$18.43$315.2K178,525Dec 3, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
17,500——84,375Dec 3, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
17,500$5.28$92.4K195,625Dec 3, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
17,500$18.07$316.2K178,125Nov 15, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
PURCHASE
Chief Medical Officer
12,235$5.28$64.6K195,625Nov 15, 2018Nov 30, 2020 ↗View →
DNLI
DENALI THERAPEUTICS INC.
SALE
Chief Medical Officer
12,235——101,875Nov 15, 2018Nov 30, 2020 ↗View →
Other insiders · DNLI
Loading peer insiders…
About this filer
CIK 0001724605
ROLE
Chief Medical Officer
PRIMARY
DNLI
COMPANIES
3
ACTIVE SINCE
Nov 2018
MARKETPEEL · /INSIDER/0001724605DATA · SEC EDGAR · FORM 4 · CONSOLIDATED TAPE
FREE · DAILY · 6 AM ET

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One short email. Insider buys, congressional trades, and plain-English analysis.

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