Clarus Lifesciences Iii, L.p.

PRAX

10% OWNER · PRAXIS PRECISION MEDICINES, INC. · CIK 0001597143

FILING MIX · LIFETIME50%/50%

BUYS

SELLS

TOTAL VALUE

$3.40M

COMPANIES

ACTIVE SINCE

Jul 2020

HOLDINGS NOW

4,894,109

AVG SELL PX

—

Trades · vs SPY

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Performance · forward returns vs SPY

1 backtested trades · 8 horizons

Forward-return performance of every backtestable P/S trade by Clarus Lifesciences Iii, L.p., measured at 8 horizons from 7 days to 2 years. Deduped per economic event so co-filings count once. Excess return = trade return minus SPY return over the same window.

HORIZON	TRADES	WIN RATE	INSIDER RETURN	SPY RETURN	MEAN EXCESS	MEDIAN EXCESS	T-STAT
7d	1	+100.00%	+6.89%	+2.77%	+4.13%	+4.13%	—
14d	1	+100.00%	+33.07%	+3.62%	+29.45%	+29.45%	—
30d	1	+100.00%	+32.69%	+8.46%	+24.23%	+24.23%	—
60d	1	+100.00%	+27.85%	+2.76%	+25.09%	+25.09%	—
90d	1	+100.00%	+38.80%	+6.10%	+32.70%	+32.70%	—
180d	1	+100.00%	+41.74%	+20.68%	+21.07%	+21.07%	—
1y	1	+100.00%	+21.46%	+38.68%	-17.22%	-17.22%	—
2y	1	+0.00%	-70.71%	+30.15%	-100.86%	-100.86%	—

How to read this: Insider Returnis the average raw return of the filer's trades over the horizon. SPY Return is what SPY did over those same windows — reference only, not a comparison. The headline alpha number is Mean Excess = Insider − SPY; green means the filer beat SPY, red means they trailed it. Win rate is the share of individual trades where the filer beat SPY. T-statvalues above 2 mean the alpha is unlikely to be chance given the sample size. "Pending" counts trades where the horizon hasn't elapsed yet; their stats are not included in the row average.

Holdings over time

PRAX · 4,894,109 shares · as of May 12, 2021

Trading cadence · quarterly flow

BUY ● SELL ●

2020

2021

FLOW · 11 buys / 11 sellsCOVERAGE · 4 quarters

Form 4 filings · all activity

COMPANY	TYPE	SHARES	PRICE	VALUE	HELD AFTER	TRADE DATE	FILED
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	2,700,000	—	—	4,894,109	May 12, 2021	May 14, 2021 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	1,410,477	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	1,941,748	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	559,208	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	907,378	—	—	907,378	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	261,318	—	—	7,429,277	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	7,375,799	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	5,052,852	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	3,446,711	—	—	4,147,645	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	659,116	—	—	7,167,959	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	SALE	352,734	—	—	0	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	2,361,198	—	—	6,508,843	Oct 20, 2020	Oct 22, 2020 ↗
PRAX PRAXIS PRECISION MEDICINES, INC.	PURCHASE	164,832	—	—	7,594,109	Oct 20, 2020	Oct 22, 2020 ↗
ANNX ANNEXON, INC.	PURCHASE	200,000	$17.00	$3.40M	2,730,635	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	PURCHASE	697,860	—	—	2,291,202	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	PURCHASE	643,208	—	—	643,208	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	SALE	5,666,667	—	—	0	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	SALE	8,370,685	—	—	0	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	PURCHASE	950,134	—	—	1,593,342	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	PURCHASE	239,433	—	—	2,530,635	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	SALE	6,148,147	—	—	0	Jul 28, 2020	Jul 30, 2020 ↗
ANNX ANNEXON, INC.	SALE	2,109,407	—	—	0	Jul 28, 2020	Jul 30, 2020 ↗

Other insiders · PRAX

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About this filer

CIK 0001597143

ROLE

10% Owner

PRIMARY

PRAX

COMPANIES

ACTIVE SINCE

Jul 2020

MARKETPEEL · /INSIDER/0001597143DATA · SEC EDGAR · FORM 4 · CONSOLIDATED TAPE

Clarus Lifesciences Iii, L.p.

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