MarketPeel
Insider Trading Intelligence
Pricing
…
PO

Patrick R. O'neil

IONS
EVP CLO & GENERAL COUNSEL · IONIS PHARMACEUTICALS INC · CIK 0001564926
FILING MIX · LIFETIME49%/51%
BUYS
54
SELLS
56
TOTAL VALUE
$33.37M
COMPANIES
1
ACTIVE SINCE
Jan 2020
HOLDINGS NOW
61,470
AVG SELL PX
$59.52
TRADE KIND
SHOWING 110 / 110
Trades · vs SPY
Loading price series…
Performance · forward returns vs SPY
32 backtested trades · 8 horizons · 37 pendingHow are these numbers computed? →
Forward-return performance of every backtestable P/S trade by Patrick R. O'neil, measured at 8 horizons from 7 days to 2 years. Deduped per economic event so co-filings count once. Excess return = trade return minus SPY return over the same window.
HORIZONTRADESWIN RATEINSIDER RETURNSPY RETURNMEAN EXCESSMEDIAN EXCESST-STAT
7d32+40.63%+1.52%+0.61%+0.92%+1.87%1.29
14d32+40.63%+0.58%+0.41%+0.17%-1.20%0.16
30d32+46.88%+0.79%+0.40%+0.38%+2.58%0.22
60d32+56.25%+0.85%+0.77%+0.08%+0.09%0.03
90d32+56.25%+3.43%+2.06%+1.38%+4.96%0.41
180d32(3 pending)+27.59%+11.46%+5.90%+5.56%+12.60%—
1y32(15 pending)+52.94%+28.86%+19.80%+9.06%-2.35%—
2y32(19 pending)+53.85%+10.00%+42.82%-32.81%-44.94%—
How to read this: Insider Returnis the average raw return of the filer's trades over the horizon. SPY Return is what SPY did over those same windows — reference only, not a comparison. The headline alpha number is Mean Excess = Insider − SPY; green means the filer beat SPY, red means they trailed it. Win rate is the share of individual trades where the filer beat SPY. T-statvalues above 2 mean the alpha is unlikely to be chance given the sample size. "Pending" counts trades where the horizon hasn't elapsed yet; their stats are not included in the row average.
Holdings over time
IONS · 61,470 shares · as of Jun 26, 2026
022,89845,79668,69391,591202120222023202420252026SHARES HELD
Trading cadence · quarterly flow
BUY ● SELL ●
2020
2020
2020
2020
2021
2021
2021
2021
2022
2022
2022
2022
2023
2023
2023
2023
2024
2024
2024
2024
2025
2025
2025
2025
2026
2026
FLOW · 54 buys / 56 sellsCOVERAGE · 26 quarters
Form 4 filings · all activity
COMPANYTYPESHARESPRICEVALUEHELD AFTERTRADE DATEFILEDDETAILS
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
3,069$80.00$245.5K61,470Jun 26, 2026Jun 30, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
10,148$75.25$763.7K62,211Mar 9, 2026Mar 11, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
376$48.87$18.4K72,359Feb 27, 2026Mar 3, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
6,179$83.53$516.2K71,983Jan 30, 2026Feb 2, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
11,991——78,162Jan 29, 2026Feb 2, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
9,191$75.84$697.0K66,171Jan 16, 2026Jan 20, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
21,473——75,362Jan 15, 2026Jan 20, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
21,473——39,251Jan 15, 2026Jan 20, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
9,675——48,926Jan 15, 2026Jan 20, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
25,800——90,601Jan 15, 2026Jan 20, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
19,350——19,350Jan 2, 2026Jan 5, 2026 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
10,200$52.87$539.3K67,330Oct 6, 2025Oct 8, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
10,200——17,000Oct 6, 2025Oct 8, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
3,241$69.27$224.5K53,889Oct 6, 2025Oct 8, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
10,200$69.89$712.8K57,130Oct 6, 2025Oct 8, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
30,203$67.69$2.04M57,130Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
34,461——0Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
34,461$60.89$2.10M91,591Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
30,203——0Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
34,461$67.69$2.33M57,130Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
30,203$56.78$1.71M87,333Oct 2, 2025Oct 2, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
14,827$56.78$841.9K71,957Sep 30, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
14,827——30,203Sep 30, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
14,827$64.68$959.0K57,130Sep 30, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
10,473$56.78$594.7K67,603Sep 29, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
10,473$64.54$675.9K57,130Sep 29, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
10,473——45,030Sep 29, 2025Sep 30, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
1,700$64.58$109.8K57,130Sep 12, 2025Sep 15, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,700——55,503Sep 12, 2025Sep 15, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
1,700$56.78$96.5K58,830Sep 12, 2025Sep 15, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
1,000$64.56$64.6K57,130Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
1,000$56.78$56.8K58,130Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
20,000——34,461Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,000——57,203Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
20,000$64.56$1.29M57,130Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
20,000$60.89$1.22M77,130Sep 9, 2025Sep 10, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
49,800$53.77$2.68M57,130Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
11,375$61.42$698.7K7,330Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
14,000$37.58$526.1K71,130Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
65,475$60.89$3.99M5,655Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
14,000——8,942Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
13,050$32.60$425.4K18,705Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
49,800——0Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
13,050——4,467Sep 3, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
13,050$54.51$711.4K57,130Sep 2, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
13,050$32.60$425.4K70,180Sep 2, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
13,050——17,517Sep 2, 2025Sep 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
331$27.71$9.2K57,130Aug 29, 2025Sep 3, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
554$28.21$15.6K56,799Feb 28, 2025Mar 4, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
1,207$32.35$39.0K56,245Feb 20, 2025Feb 24, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
6,165$31.62$194.9K57,452Feb 4, 2025Feb 5, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,406$32.49$45.7K63,617Jan 31, 2025Feb 3, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
3,820——65,023Jan 30, 2025Feb 3, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
7,360$32.83$241.6K61,203Jan 16, 2025Jan 17, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
22,000——64,801Jan 15, 2025Jan 17, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
33,000——80,414Jan 15, 2025Jan 17, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
19,690——68,563Jan 15, 2025Jan 17, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
19,690——60,724Jan 15, 2025Jan 17, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
22,000——22,000Jan 2, 2025Jan 3, 2025 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
246$38.64$9.5K48,873Aug 30, 2024Sep 4, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,961$49.67$97.4K48,661Feb 2, 2024Feb 2, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,995$49.67$99.1K48,627Feb 2, 2024Sep 4, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
3,820——50,622Feb 1, 2024Feb 2, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
6,450$51.75$333.8K46,802Jan 25, 2024Jan 29, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
7,744$50.42$390.4K53,252Jan 17, 2024Jan 18, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
20,641——60,996Jan 16, 2024Jan 18, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
20,641——47,414Jan 16, 2024Jan 18, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
17,000——42,801Jan 15, 2024Jan 17, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
20,400——68,055Jan 15, 2024Jan 17, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
27,200——27,200Jan 2, 2024Jan 4, 2024 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
20,825——0Dec 26, 2023Dec 28, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
20,825$47.34$985.9K61,180Dec 26, 2023Dec 28, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
20,825$51.46$1.07M40,355Dec 26, 2023Dec 28, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE10b5-1
10b5-1 plan
1,527$41.70$63.7K40,355May 24, 2023May 24, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
301$30.52$9.2K41,882Feb 28, 2023Mar 1, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
1,920$40.86$78.5K41,581Feb 6, 2023Feb 7, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
3,822——43,501Feb 3, 2023Feb 7, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
4,500$39.71$178.7K39,679Jan 31, 2023Jan 31, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
4,500$39.42$177.4K44,179Jan 30, 2023Jan 31, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
7,836$39.49$309.5K48,679Jan 18, 2023Jan 19, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
21,871——56,515Jan 17, 2023Jan 19, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
21,871——47,655Jan 17, 2023Jan 19, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
17,207——69,526Jan 15, 2023Jan 18, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
14,338——25,801Jan 15, 2023Jan 18, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
22,942——22,942Jan 3, 2023Jan 4, 2023 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
108$28.97$3.1K34,644Aug 31, 2022Sep 1, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
6,792$40.06$272.1K34,536Apr 12, 2022Apr 13, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
735$28.37$20.9K41,328Feb 28, 2022Mar 2, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP CLO & General Counsel
21,086——48,094Jan 18, 2022Jan 20, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
7,501$30.12$225.9K40,593Jan 18, 2022Jan 20, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP CLO & General Counsel
21,086——52,319Jan 18, 2022Jan 20, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
11,463——11,463Jan 15, 2022Jan 19, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
15,284——73,405Jan 15, 2022Jan 19, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
30,567——30,567Jan 3, 2022Jan 5, 2022 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP Legal & General Counsel
309$33.80$10.4K27,008Aug 31, 2021Sep 2, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP & General Counsel
197$44.54$8.8K26,699Feb 26, 2021Mar 2, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP & General Counsel
5,324$63.50$338.1K26,502Jan 25, 2021Jan 27, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
25,868——25,868Jan 15, 2021Jan 20, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP & General Counsel
16,504——32,253Jan 15, 2021Jan 20, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP & General Counsel
16,504——37,682Jan 15, 2021Jan 20, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
EVP & General Counsel
5,856$61.28$358.9K31,826Jan 15, 2021Jan 20, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
58,203——58,203Jan 4, 2021Jan 6, 2021 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
EVP & General Counsel
169$44.46$7.5K21,178Aug 31, 2020Sep 2, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
SVP & General Counsel
289$43.16$12.5K21,009Feb 29, 2020Mar 3, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
SVP & General Counsel
3,882$59.60$231.4K20,720Feb 10, 2020Feb 11, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
SVP, Legal & General Counsel
12,045——24,552Jan 15, 2020Jan 17, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASE
SVP, Legal & General Counsel
12,045——28,879Jan 15, 2020Jan 17, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
24,205——24,205Jan 15, 2020Jan 17, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
SALE
SVP, Legal & General Counsel
4,277$62.06$265.4K24,602Jan 15, 2020Jan 17, 2020 ↗View →
IONS
IONIS PHARMACEUTICALS INC
PURCHASEGRANT
Stock grant
54,461——54,461Jan 2, 2020Jan 3, 2020 ↗View →
Other insiders · IONS
Loading peer insiders…
About this filer
CIK 0001564926
ROLE
EVP CLO & General Counsel
PRIMARY
IONS
COMPANIES
1
ACTIVE SINCE
Jan 2020
MARKETPEEL · /INSIDER/0001564926DATA · SEC EDGAR · FORM 4 · CONSOLIDATED TAPE
FREE · DAILY · 6 AM ET

The morning brief, before the bell.

One short email. Insider buys, congressional trades, and plain-English analysis.

Feedback